Cardiomyocyte Lineage Specification in€Adult Human Cardiac Precursor Cells Via€Modulation of Enhancer-Associated Long Noncoding RNA Expression
نویسندگان
چکیده
rom the Experimental Cardiology Unit, Department of Medicine, University of Laus witzerland; Department of Physiology, University of Bern, Bern, Switzerland; and the Depa niversity of Lausanne Medical School, Lausanne, Switzerland. This project was supported in p e Swiss National Science Foundation, Bern, Switzerland (grants no 33CM30-124090 and no 4 oundation for Medical-Biological Research, Basel, Switzerland (grant no 15A048). The author lationships relevant to the contents of this paper to disclose.
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Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease
The key information processing units within gene regulatory networks are enhancers. Enhancer activity is associated with the production of tissue-specific noncoding RNAs, yet the existence of such transcripts during cardiac development has not been established. Using an integrated genomic approach, we demonstrate that fetal cardiac enhancers generate long noncoding RNAs (lncRNAs) during cardiac...
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